Qing-Hui Chen

Contact

qinghuic@mtu.edu
906-487-1629
Dow 407

Download CV

Professor, Kinesiology and Integrative Physiology
Affiliated Professor, Biological Sciences
Affiliated Professor, Biomedical Engineering

PhD, Kagawa University Medical School, Japan
MS, Medical School of Southeast University, China
MD, Nantong University College of Medicine, China

Research Interests

Cardiovascular physiology, neurophysiology and exercise science.
Neural mechanisms of cardiovascular diseases and metabolic disorders.
Neural mechanisms of exercise training in regulating autonomic and cardiovascular function.

Recent Publications

1. Guo X, Zhang J, Zhu J, Chen QH, Wang R, Gui L. Enhanced Store-Operated Calcium Entry in Platelets is Associated with acute coronary syndrome. Acta Biochim Biophys Sin (Shanghai). 2020 Feb 3;52(2):207-210.

2. Bruning J, Chapp A, Kaurala GA, Wang R, Techtmann S, Chen QH*. Gut Microbiota and Short Chain Fatty Acids: Influence on the Autonomic Nervous System. Neurosci Bull. 2020 Jan;36(1):91-95

3. Sharma D, Jia W, Long F, Pati S, Chen QH, Qyang Y, Lee B, Choi CK, Zhao F. Polydopamine and collagen coated micro-grated polydimethylsiloxane for human mesenchymal stem cell culture. Bioact Mater. Bioact Mater. 2019 Dec;4:142-150.

4. Cheng ZJ, Wang R and Chen QH*. Autonomic Regulation of Cardiovascular System: Diseases, Treatments, and Novel Approaches. Editorial for Special Issue on Regulation of Autonomic Nervous System. Neuroscience Bulletin; Editorial 2019 Feb; 35(1):1-3. https://link.springer.com/journal/12264/35/1

5. Chapp AD, Behnke JE, Driscoll KM, Fan Y, Hoban E, Shan Z, Zhang L, Chen QH*. Acetate Mediates Alcohol Excitotoxicity in Dopaminergic-Like PC12 Cells. ACS Chem Neurosci 2019 Jan 16;10(1):235-245.

6. Wu JX, Tong L, Hu L, Xia CM, Li M, Chen QH, Chen FX, Du DS. Upregulation of Nav1. 6 expression in the rostral ventrolateral medulla of stress-induced hypertensive rats. Hypertension Research 2018 Dec;41(12):1013-1022

7. Peng T, Qiao M, Liu H, Teotia S, Zhang Z, Zhao Y, Wang B, Zhao D, Shi L, Zhang C, Le B, Rogers K, Gunasekara C, Duan H, Gu Y, Tian L, Nie J, Qi J, Meng F, Huang L, Chen QH, Wang Z, Tang J, Tang X, Lan T, Chen X, Wei H, Zhao Q, Tang G. A Resource for Inactivation of microRNAs Using Short Tandem Target Mimic Technology in Model and Crop Plants. Mol Plant. 2018 Nov 5;11(11):1400-1417

8. Gui L, Guo X, Zhang Z, Xu H, Ji Y, , Wang R, Zhu J, Chen QH*. Activation of CaMKIIδA promotes Ca2+ leak from the sarcoplasmic reticulum in cardiomyocytes of chronic heart failure rats. Acta Pharmacol Sin. 2018 Oct; 39(10):1604-1612.

9. Chapp AD, Schum S, Behnke JE, Shan Z, Chen QH*. Measurement of cations, anions, and acetate in serum, urine, cerebrospinal fluid, and tissue by ion chromatography. Physiological Report 2018 Apr;6(7):e13666. doi: 10.14814/phy2.13666

10. Huber MJ, Chen QH, Shan Z. The Orexin System and Hypertension. Cell Mol Neurobiol. 2018 Mar;38(2):385-391.

11. Jiang E, Chapp AD, Fan Y, Larson RA, Hahka T, Huber MJ, Yan J, Chen QH, Shan Z. Expression of proinflammatory cytokines is upregulated in the hypothalamic paraventricular nucleus of Dahl salt-sensitive hypertensive rats. Frontiers Physiol. 2018 Feb 22;9:104 (p1-15).

12. Fan Y, Jiang E, Hahka T, Chen QH,* Yan J*, Shan Z*. Orexin A increases sympathetic nerve activity through promoting expression of proinflammatory cytokines in Sprague Dawley rats. Acta Physiol 2018 Feb. 222(2):1-15.

More publications are available in Download CV.

Recent Funding

NIH 1R15HL145655 “Neural Mechanism of Sympathetic Activation in Heart Failure” (PI)

NIH 1R01HL146652 “Engineered Anisotropic and Vascularized Human Cardiac Patch” (co-I)

NIH 1R15HL129213 “Prorenin receptor and sympathetic activation in salt-sensitive hypertension” (co-I)

NIH 1R15HL122952 “ER Stress and Reduced SK Channel Function in PVN in Rats with High Salt Intake” (PI)

More funding history are available in Download CV.

Presentations

1. J. Bruning, R. Ghannam, QH. Chen, Z. Shan, G. Miodonski, S. Techtmann, A. Chapp. Microbial Derived Short Chain Fatty-Acids and Autonomic Regulation of Cardiovascular Function. Experiment Biology 2020 (San Diego, USA. April 04-07, 2020).The FASEB Journal 34s1.06549.

2. H. Gao, C. Bloch, B. Chen, J. Bigalke, QH. Chen, Z. Shan. Plasma Orexin A Level is Increased in Salt‐Sensitive Hypertension. Experiment Biology 2020 (San Diego, USA. April 04-07, 2020).The FASEB Journal 34s1.07616

3. J. Bruning, A. Chapp, S. Schum, J. Behnke, Z. Shan, L. Zhang, QH. Chen. Gender Differences In Acetic Acid/Acetate Production From Ethanol Metabolism. Research Society on Alcoholism 2019 (Minneapolis, June 22-26, 2019). Alcoholism-Clinical And Experimental Research 43, 222A-222A.

4. A. Chapp, K. Driscoll, M. Huber, Z. Shan, L. Zhang, QH. Chen. Acetate Increase Sympathetic Nerve Activity Via Activation Of NMDA Receptors In Automatic Amygdala Neurons. Research Society on Alcoholism 2019 (Minneapolis, June 22-26, 2019). Alcoholism-Clinical And Experimental Research 43, 267A-267A.

5. WF Alharbi, J Bigalke, QH Chen, ZJ Shan. Orexin A receptor 1(OX1R) activation increases expression of cytokines in PC12 cells. . Experiment Biology 2019 (Orlando, FL, USA. April 05-10, 2019). The FASEB Journal 33 (1_supplement), 692.10-692.10

6. JA Bigalke, QH Chen, Z Shan. Orexin Function in DOCA-Salt Rat Model. Experiment Biology 2019 (Orlando, FL, USA. April 05-10, 2019). The FASEB Journal 33 (1_supplement), 835.5-835.5

7. Qing-Hui Chen. “Exercise and Autonomic Regulation of Cardiovascular Function”. Oral Presentation. Invited featured faculty talk in China Heart Congress (2018CHC) Sponsored by Chinese Medical Association and National Center for Cardiovascular Diseases. (China National Conversion Center, Peking, China. Aug. 4-8, 2018)

8. A. Chapp, M. Huber, R. Larson, Z. Shan, L. Zhang, QH. Chen. Aldehyde dehydrogenase inhibitor, cyanamide, attenuates ethanol induced sympathoexcitatory response in the central nucleus of amygdala. Research Society on Alcoholism 2018 (San Diego, June 16-20, 2018). Alcoholism-Clinical And Experimental Research 42, 152A-152A

9. A Chapp, J Behnke, K Driscoll, Y Fan, Z Shan, L Zhang, QH Chen. Acetate mediates ethanol toxicity in dopaminergic-like PC12 cells. Research Society on Alcoholism 2018 (San Diego, June 16-20, 2018). Alcoholism-Clinical And Experimental Research 42, 36A-36A

10. Zoe' LaLonde, JE Behnke, AD Chapp, Z Shan, QH Chen. L-lactate Increases Apoptosis in Dopaminergic-Like PC12 Cells. Experiment Biology 2018 (Chicago, USA. April 21-25, 2018). The FASEB Journal 32 (1_supplement), lb468-lb468

11. JE Behnke, AD Chapp, Z Shan, QH Chen. Nicotine Attenuates Acetate-Induced Increase of Cytosolic Reactive Oxygen Species in Dopaminergic-Like PC12 Cells. Experiment Biology 2018 (Chicago, USA. April 21-25, 2018). The FASEB Journal 32 (1_supplement), 616.8-616.8

12. AD Chapp, S Schum, JE Behnke, MJ Huber, E Jiang, RA Larson, Z Shan, QH Chen. Measurement of Electrolytes, Including Acetate in Various Physiological Samples Using Ion Chromatography. Experiment Biology 2018 (Chicago, USA. April 21-25, 2018). The FASEB Journal 32 (1_supplement), 844.3-844.3

13. TH Hahka, YY Fan, QH Chen, ZJ Shan. High Salt Diet May Stimulate Fructose Uptake in Brain Neurons and Contribute to Neuronal Apoptosis. Experiment Biology 2018 (Chicago, USA. April 21-25, 2018). The FASEB Journal 32 (1_supplement), 847.14-847.14

14. JA Bigalke, EJ Jiang, TM Hahka, QH Chen, ZJ Shan. PVN Orexin Receptor 1 Knockdown Effect on Metabolism and Fluid Homeostasis. Experiment Biology 2018 (Chicago, USA. April 21-25, 2018). The FASEB Journal 32 (1_supplement), lb465-lb465

More presentations are available in Download CV.

Teaching Experience

Advanced Exercise Integrative Physiology

Cardiac Electrophysiology and ECG Interpretation

Cardiopulmonary Physiology

Exercise Pharmacology

Neuroendocrine Physiology

Research in Biochemistry

Graduate Seminar