Robert A. Larson

Contact

ralarson@mtu.edu
906-487-2254
Dow 409

Assistant Professor, Biological Sciences

PhD, Biological Sciences, Michigan Technological University
MS, Biological Sciences, Michigan Technological University
BS, Business Administration Michigan Technological University
BS, Clinical Laboratory Science, Northern Michigan University

Biography

Robert earned his Master’s and PhD in the Department of Biological Sciences at Michigan
Technological University studying neural-cardiovascular physiology. He completed his Post-
Doctoral fellowship in neurocardiology at The University of Iowa Carver College of Medicine
where he studied cardiac sensory and sympathetic nerves in hypertrophic cardiomyopathy and hypertension. Prior to graduate school, Robert worked in the diagnostic laboratory at Aspirus Keweenaw Hospital serving as both a Generalist and Hematology and Coagulation Supervisor.

Links of Interest

Google Scholar Profile

Research Interests

Neural Control of the Heart
Autonomic Function in Health and Disease

Recent Publications

Larson, R. A. and Chapleau, M. W. (2023). Differential engagement of inhibitory and excitatory cardiopulmonary reflexes by capsaicin and phenylbiguanide in C57BL/6 mice. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 2023 324:3, R336-R344.
Vyas, A. P., Thivierge, G. S., Toorongian, C. A., Larson, R. A. and Durocher, J. J. (2022), Mental Stress Pressor Response and Post-Stress Aortic Wave Reflection. The FASEB Journal, 36.
Larson, R. A., Chen, X., Gu, M., Shan, Z. and Chen, Q. (2022), SK Channel Dysfunction in the Hypothalamic Paraventricular Nucleus Contributes to Sympathoexcitation in Dahl Salt-Sensitive Rats. The FASEB Journal, 36.
Larson, R. A., Lu, Y. and Chapleau, M. W. (2020), Evidence that Sympathetic Activity is Increased Selectively to the Heart in a Mouse Model of Hypertrophic Cardiomyopathy. The FASEB Journal, 34: 1-1.
Chapp, A. D., Huber, M. J., Collins, A. R., Driscoll, K. M., Behnke, J. E., Larson, R. A., Shan, Z., Zhang, L., Chen, Q. (2020). Local Metabolism of Ethanol to Acetic Acid/Acetate in the Central Nucleus of Amygdala Elicits Sympathoexcitatory Responses through Activation of NMDAR in Sprague Dawley Rats. bioRxiv 2020.07.20.212597
Larson, R. A., Lu, Y., Benson, C. J. and Chapleau, M. W. (2019), Sensitization of the Cardiac Sympathetic Afferent Reflex Contributes to Increased Sympathetic Tone in a Mouse Model of Hypertrophic Cardiomyopathy. The FASEB Journal, 33: 745.4-745.4.
Larson, R. A., Lu, Y., Benson, C. J., Chapleau, M. W. (2018). Abstract P202: Targeting the Cardiac Sympathetic Afferent Reflex in Hypertrophic Cardiomyopathy. Hypertension. 2018;72:AP202.
Larson, R. A., & Chapleau, M. W. (2018). Increased cardiac sympathetic activity: Cause or compensation in vasovagal syncope?. Clinical Autonomic Research, 28(3), 265-266.
Chapp, A., Huber, M., Larson, R., Shan, Z., Zhang, L., & Chen, Q. H. (2018, June). ALDEHYDE DEHYDROGENASE INHIBITOR, CYANAMIDE, ATTENUATES ETHANOL INDUCED SYMPATHOEXCITATORY RESPONSE IN THE CENTRAL NUCLEUS OF AMYGDALA. In ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (Vol. 42, pp. 152A-152A).
Larson, R. A. and Chapleau, M. W. (2018), Chemosensitive Cardiac Afferent Reflexes in Mice: Are they Altered in Hypertrophic Cardiomyopathy?. The FASEB Journal, 32: 591.4-591.4.
Chapp, A.D., Schum, S., Behnke, J.E., Huber, M.J., Jiang, E., Larson, R. A., Shan, Z. and Chen, Q. (2018), Measurement of Electrolytes, Including Acetate in Various Physiological Samples Using Ion Chromatography. The FASEB Journal, 32: 844.3-844.3.
Chapp, A. D., Schum, S., Behnke, J. E., Hahka, T., Huber, M. J., Jiang, E., Larson, R. A., Shan, Z., Chen, Q; (2018). Measurement of cations, anions, and acetate in serum, urine, cerebrospinal fluid, and tissue by ion chromatography. Physiol Rep, 6 ( 7), 2018, e13666,
Jiang, E., Chapp A. D., Fan, Y., Larson, R. A., Hahka, T., Huber, M. J., Yan, J., Chen, Q., Shan, Z. (2018). Expression of Proinflammatory Cytokines Is Upregulated in the Hypothalamic Paraventricular Nucleus of Dahl Salt-Sensitive Hypertensive Rats. Frontiers in Physiology, Vol. 9.
Huber, M. J., Fan, Y., Jiang, E., Zhu, F., Larson, R. A., Yan, J., Li, N., Chen, Q., Shan, Z. (2017). Increased activity of the orexin system in the paraventricular nucleus contributes to salt-sensitive hypertension. American Journal of Physiology-Heart and Circulatory Physiology 2017 313:6, H1075-H1086.
Larson, R. A., Chapp, A. D., Gui, L., Huber, M. J., Cheng, Z. J., Shan, Z., & Chen, Q. (2017). High salt intake augments excitability of PVN neurons in rats: role of the endoplasmic reticulum Ca2+ store. Frontiers in Neuroscience,11, 182.
Larson, R. A., Purnell, B. S., Davis, M. K., Weiss, R. M., Cicha, M. Z., Sabharwal, R. and Chapleau, M. W. (2017), Age-Related Left Ventricular Systolic Dysfunction in a Mouse Model of Hypertrophic Cardiomyopathy. The FASEB Journal, 31: lb676-lb676.
Larson, R. A., & Carter, J. R. (2016). Total sleep deprivation and pain perception during cold noxious stimuli in humans. Scandinavian Journal of Pain, 13(1), 12-16.
Huber, M. J., Zhu, F., Larson, R. A., Chen, Q. (2016), Abstract P327: Increased Brain iNOS Contributes to Hypertension in Dahl Salt Sensitive Rats. Hypertension. 2016; 68:AP327.
Zhu, F., Larson, R. A., Shi, P., Li, N., Chen, Q. and Shan, Z. (2016), High Salt Challenge Augments Expression of Proinflammatory Cytokines and Contributes to Elevated Neuronal Activity in the Hypothalamic Paraventricular Nucleus. The FASEB Journal, 30: 757.14-757.14.
Larson, R. A., Chapp, A. D., Cheng, Z., Shan, Z. and Chen, Q. (2016), Diminished Intracellular Calcium in the Hypothalamic Paraventricular Nucleus Augments Neuronal Excitability and Sympathetic Nerve Activity. The FASEB Journal, 30: 757.13-757.13.
Larson, R. A. (2016). Central neural mechanisms of salt-sensitive hypertension (Order No. 10168415). Available from Dissertations & Theses @ Michigan Technological University; SciTech Premium Collection.
Larson, R. A., Gui, L., Huber, M. J., Chapp, A. D., Zhu, J., LaGrange, L. P., ... & Chen, Q. (2015). Sympathoexcitation in ANG II-salt hypertension involves reduced SK channel function in the hypothalamic paraventricular nucleus. American Journal of Physiology-Heart and Circulatory Physiology, 308(12), H1547-H1555.

Teaching Experience

Introduction to Neuroscience
Medical Mycology & Virology
Hematology & Hemostasis