Shiyue Fang

Contact

shifang@mtu.edu
906-487-2023
Chem Sci 620C

Professor, Chemistry

Postdoctoral, Purdue University, West Lafayette, Indiana
PhD, University of Missouri, St. Louis, Missouri

Biography

Dr. Shiyue Fang is a synthetic organic chemist. He obtained PhD in organometallic chemistry and conducted postdoctoral study in nucleic acid chemistry. Currently, projects in his research group include the development of technologies for sensitive DNA and RNA synthesis and non-chromatographic purification of DNA and peptide, synthesis of mono-disperse polyethylene glycol and derivatives, discovery of new organic transformations, and the use of organic synthesis to address fundamental physical chemical and biological questions.

Links of Interest

Research Group Page

Research Interests

Organic Synthesis
Nucleic Acid and Peptide Chemistry
Organometallic Chemistry
Mechanochemistry
Epigenetics and Chemical Biology
Antisense Drug

Recent Publications

Dhananjani N. A. M. Eriyagama, Yipeng Yin, Shiyue Fang. Automated Stepwise PEG Synthesis Using a Base-Labile Protecting Group. Tetrahedron 2022, 119, 132861.
Komal Chillar, Yipeng Yin, Dhananjani N. A. M. Eriyagama, Shiyue Fang. Determination of Optical Density (OD) of Oligodeoxynucleotides from HPLC Peak Area. ChemRxiv [Preprint], 2022, March, 15. doi:10.26434/chemrxiv-2022-hdqzr. Open Access
Logan Mikesell, Dhananjani N. A. M. Eriyagama,+ Yipeng Yin,+ Bao-Yuan Lu, Shiyue Fang. Stepwise PEG Synthesis Featuring Deprotection and Coupling in One Pot. Beilstein Journal of Organic Chemistry 2021, 17, 2976-2982. Open Access funded by Beilstein-Institut (+ Equal contributors)
Shiyue Fang. The Ion Pair Thermal Model of MALDI MS. ChemRxiv [Preprint], 2021, October, 19. doi:10.33774/chemrxiv-2021-qkd7w. Open Access.
Shiyue Fang, Dhananjani Eriyagama, Yinan Yuan, Shahien Shahsavari, Jinsen Chen, Xi Lin, Bhaskar Halami. Dim and Dmoc Protecting Groups for Oligodeoxynucleotide Synthesis. Current Protocols in Nucleic Acid Chemistry, 2020, 82, e111. doi:10.1002/cpnc.111.
Bhaskar Halami, Dhananjani N. A. M. Eriyagama, Komal Chillar, Zack Nelson, Lucas Prehoda, Yipeng Yin, Bao-Yuan Lu, Brett Otto, Liam Haggerty, Shiyue Fang. Linear Oligosulfoxides: Synthesis and Solubility Studies. Tetrahedron Letters, 2019, 60, 151306.
Shahien Shahsavari, Dhananjani Eriyagama, Jinsen Chen, Bhaskar Halami, Yipeng Yin, Komal Chillar, Shiyue Fang. Sensitive Oligodeoxynucleotide Synthesis Using Dim and Dmoc as Protecting Groups. The Journal of Organic Chemistry 2019, 84, 13374-13383.
Shahien Shahsavari, Dhananjani N. A. M. Eriyagama, Bhaskar Halami, Vagarshak Begoyan, Marina Tanasova, Jinsen Chen, Shiyue Fang. Electrophilic Oligodeoxynucleotide Synthesis using dM-Dmoc for Amino Protection. Beilstein Journal of Organic Chemistry 2019, 15, 1116-1128.
Dhananjani N. A. M. Eriyagama, Shahien Shahsavari, Bhaskar Halami, Bao-Yuan Lu, Fengping Wei, Shiyue Fang. Parallel, Large Scale and Long Synthetic Oligodeoxynucleotide Purification Using the Catching Full-length Sequence by Polymerization Technique. Organic Process Research and Development 2018, 22, 1282-1288.
Bhaskar Halami, Shahien Shahsavari, Zack Nelson, Lucas Prehoda, Dhananjani N. A. M. Eriyagama, Shiyue Fang. Incorporation of Sensitive Ester and Chloropurine Groups into Oligodeoxynucleotides through Solid Phase Synthesis. ChemistrySelect 2018, 3, 8857-8862.
Shahien Shahsavari, Chase McNamara, Mark Sylvester, Emily Bromley, Savannah Joslin, Bao-Yuan Lu, Shiyue Fang. Amine Protecting Groups Deprotectable under Nearly Neutral Oxidative Conditions. Beilstein Journal of Organic Chemistry 2018, 14, 1750-1757.
Shahien Shahsavari, Travis Wigstrom, James Gooding, Chase McNamara, Shiyue Fang. dM-Dim for Carboxylic Acid Protection. Tetrahedron Letters 2018, 59, 1763-1766.

Recent Funding

Teaching Experience

Organic Chemistry (CH2420)
Organometallic Chemistry (CH4490, CH6490)
Intermediate Organic Chemistry (CH4430)
Spectroscopy of Organic Chemistry (CH4412)
Advanced Organic Chemistry (CH5420)
General Organic and Biochemistry (CH1140)
Chemistry Orientation (CH1130)