Jiehong Guo

Contact

jiehongg@mtu.edu
906-487-3533
Dow 861

Assistant Professor, Civil, Environmental, and Geospatial Engineering

PhD, Public Health, University of Illinois at Chicago
MS, Environmental Engineering, Beijing Technology and Business University, China
BS, Bioengineering, Chang'an University, China

Biography

Before joining Michigan Tech, Dr. Jiehong Guo was a senior researcher at the University of Minnesota Twin Cities. She has previously worked in Indiana University Bloomington as a Postdoctoral Research Associate. Her research focuses on two parts. One is to identify biomarkers of DNA damage caused by carcinogens using mass spectrometric approaches. Another part is to develop and apply analytical methods to measure persistent, bioaccumulative and toxic (PBT) pollutants in various environmental matrices, evaluate the magnitude of environmental pollution, and examine the fate and transport of PBT chemicals in the environment. Dr. Guo has published over 35 peer reviewed papers in Environmental Science and Technology, Chemical Research in Toxicology, Journal of Hazardous Materials, etc.

Links of Interest

Jiehong Guo in ResearchGate

Research Interests

Qualitative and quantitative mass spectrometry application
Persistent, bioaccumulative, and toxic pollutants (PBTs) monitoring
Fate and transport of PBTs in aquatic environment
Biomarkers of DNA damage induced by carcinogens

Recent Publications

Jiehong Guo, Stephen S. Hecht. DNA damage in human oral cells induced by use of e-cigarettes. Drug Testing and Analysis, 2022; 1- 9. doi:10.1002/dta.3375
Jiehong Guo, Joshua Ikuemonisan, Dorothy K. Hatsukami, Stephen S. Hecht. Liquid chromatography-nanoelectrospray ionization-high resolution tandem mass spectrometry analysis of apurinic/apyrimidinic sites in oral cell DNA of cigarette smokers, e-cigarette users and nonsmokers. Chemical Research in Toxicology, 34 (12), 2540-2548, 2021.
Jiehong Guo, Haoqing Chen, Pramod Upadhyaya, Yingchun Zhao, Robert J. Turesky, Stephen S. Hecht. Mass spectrometric quantitation of apurinic/apyrimidinic sites in tissue DNA of rats exposed to tobacco-specific nitrosamines and in lung and leukocyte DNA of cigarette smokers and nonsmokers. Chemical Research in Toxicology, 33 (9), 2475–2486, 2020.
Jiehong Guo, Zhuona Li, Prabha Ranasinghe, Karl J. Rockne, Neil C. Sturchio, John P. Giesy, An Li. Halogenated flame retardants in sediments from the Upper Laurentian Great Lakes: Implications to long-range transport and evidence of long-term transformation. Journal of Hazardous Materials, 384, 121346, 2020.
Jiehong Guo, William Stubbings, Kevin Romanak, Linh V. Nguyen, Liisa Jantunen, Lisa Melymuk, Victoria Arrandale, Miriam L. Diamond and Marta Venier. An Alternative Flame Retardant, 2,4,6-Tris(2,4,6-tribromophenoxy)-1,3,5-triazine (TTBP-TAZ), in an E-waste Recycling Facility and House Dust in North America, Environmental Science and Technology, 52 (6), 3599-3607, 2018.

Recent Funding

NIH/NCI R03 CA- 259652 Guo, J (PI) 01/31/2022 – 12/31/2024
Carcinogenic tobacco-specific nitrosamines induction of apurinic/apyrimidinic sites in DNA of human oral cells
Cigarette smoke, smokeless tobacco and electronic cigarettes may induce DNA damage and cause lung and oral cavity cancer. We will quantify DNA damage in oral cells of humans exposed to different types of tobacco products in order to provide an effective biomarker of human exposure to carcinogens. Our goal is to advance our understanding of tobacco-induced cancer and ultimately develop effective strategies for cancer prevention